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Finally, none of the trials included HF in the primary composite outcome, although all trials prospectively adjudicated HF events as secondary outcomes

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In the 1970s, Holst recorded intestinal surgery patients experiencing insulin spikes and drops in blood sugar after meals, leading him to conclude that an incretin, subsequently identified as GLP-1, along with insulin and glucagon was responsible for the glucose-induced gastrointestinal stimulation of insulin secretion that caused the changes in blood sugar levels

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Fujimura N, Hata T, Soga J, Hidaka T, Idei N, Fujii Y, et al